|Other Names||Oxysterol-binding protein-related protein 10, ORP-10, OSBP-related protein 10, OSBPL10, ORP10, OSBP9|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (PubMed:23934110) (Probable). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110).|
|Cellular Location||Cytoplasm, cytoskeleton Note=Associates with microtubules.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the oxysterol-bindingprotein (OSBP) family, a group of intracellular lipid receptors.Like most members, the encoded protein contains an N-terminalpleckstrin homology domain and a highly conserved C-terminalOSBP-like sterol-binding domain. Multiple transcript variantsencoding different isoforms have been found for this gene.
Koriyama, H., et al. J. Atheroscler. Thromb. 17(10):1054-1062(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Koriyama, H., et al. Hypertens. Res. 33(5):511-514(2010)Perttila, J., et al. J. Mol. Med. 87(8):825-835(2009)Ma, J., et al. Atherosclerosis 191(1):63-72(2007)
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