|Other Names||Protein SSX3, Cancer/testis antigen 53, CT53, SSX3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Could act as a modulator of transcription.|
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The product of this gene belongs to the family of highlyhomologous synovial sarcoma X (SSX) breakpoint proteins. Theseproteins may function as transcriptional repressors. They are alsocapable of eliciting spontaneously humoral and cellular immuneresponses in cancer patients, and are potentially useful targets incancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes havebeen involved in the t(X;18) translocation characteristically foundin all synovial sarcomas. This gene appears not to be involved inthis type of chromosome translocation. Two transcript variantsencoding distinct isoforms have been identified for this gene.
Ross, M.T., et al. Nature 434(7031):325-337(2005)Gure, A.O., et al. Int. J. Cancer 101(5):448-453(2002)de Bruijn, D.R., et al. Genes Chromosomes Cancer 34(3):285-298(2002)Gure, A.O., et al. Int. J. Cancer 72(6):965-971(1997)de Leeuw, B., et al. Cytogenet. Cell Genet. 73(3):179-183(1996)
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