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EDA2R Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9HAV5
Clone Names 110717051
Peptide ID 110717051
Additional Information
Gene ID 60401
Other Names Tumor necrosis factor receptor superfamily member 27, X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, EDA2R, TNFRSF27, XEDAR
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name EDA2R
Synonyms TNFRSF27, XEDAR
Function Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.
Cellular Location Membrane; Single-pass type III membrane protein
Research Areas
Citations (0)

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EDA-A1 and EDA-A2 are two isoforms of ectodysplasin thatare encoded by the anhidrotic ectodermal dysplasia (EDA) gene.Mutations in EDA give rise to a clinical syndrome characterized byloss of hair, sweat glands, and teeth. The protein encoded by thisgene specifically binds to EDA-A2 isoform. This protein is a typeIII transmembrane protein of the TNFR (tumor necrosis factorreceptor) superfamily, and contains 3 cysteine-rich repeats and asingle transmembrane domain but lacks an N-terminal signal peptide.Multiple alternatively spliced transcript variants have been foundfor this gene, but some variants lack sufficient support. [providedby RefSeq].


Brockschmidt, F.F., et al. Br. J. Dermatol. 162(4):899-903(2010)Tanikawa, C., et al. Oncogene 28(34):3081-3092(2009)Fujimoto, A., et al. J. Hum. Genet. 54(8):461-465(2009)Hillmer, A.M., et al. Hum. Genet. 126(2):255-264(2009)Richards, J.B., et al. Nat. Genet. 40(11):1282-1284(2008)

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$ 80.00
Cat# BP18402b
Availability: In Stock
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