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EDA2R Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9HAV5 |
|---|---|
| Clone Names | 110717051 |
| Gene ID | 60401 |
|---|---|
| Other Names | Tumor necrosis factor receptor superfamily member 27, X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, EDA2R, TNFRSF27, XEDAR |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | EDA2R |
|---|---|
| Synonyms | TNFRSF27, XEDAR |
| Function | Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. |
| Cellular Location | Membrane; Single-pass type III membrane protein. |
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Provided below are standard protocols that you may find useful for product applications.
Background
EDA-A1 and EDA-A2 are two isoforms of ectodysplasin thatare encoded by the anhidrotic ectodermal dysplasia (EDA) gene.Mutations in EDA give rise to a clinical syndrome characterized byloss of hair, sweat glands, and teeth. The protein encoded by thisgene specifically binds to EDA-A2 isoform. This protein is a typeIII transmembrane protein of the TNFR (tumor necrosis factorreceptor) superfamily, and contains 3 cysteine-rich repeats and asingle transmembrane domain but lacks an N-terminal signal peptide.Multiple alternatively spliced transcript variants have been foundfor this gene, but some variants lack sufficient support. [providedby RefSeq].
References
Brockschmidt, F.F., et al. Br. J. Dermatol. 162(4):899-903(2010)Tanikawa, C., et al. Oncogene 28(34):3081-3092(2009)Fujimoto, A., et al. J. Hum. Genet. 54(8):461-465(2009)Hillmer, A.M., et al. Hum. Genet. 126(2):255-264(2009)Richards, J.B., et al. Nat. Genet. 40(11):1282-1284(2008)
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