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SEPSECS Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9HD40 |
|---|---|
| Clone Names | 110717180 |
| Gene ID | 51091 |
|---|---|
| Other Names | O-phosphoseryl-tRNA(Sec) selenium transferase, Liver-pancreas antigen, LP, SLA-p35, SLA/LP autoantigen, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase, Sep-tRNA:Sec-tRNA synthase, SepSecS, Soluble liver antigen, SLA, UGA suppressor tRNA-associated protein, tRNA(Ser/Sec)-associated antigenic protein, SEPSECS, TRNP48 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SEPSECS |
|---|---|
| Synonyms | TRNP48 |
| Function | Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
The 21st amino acid, selenocysteine (sec), is distinctfrom other amino acids because it lacks its own tRNA synthetase andis the only amino acid synthesized on its cognate tRNA. Synthesisof sec begins with acylation of tRNA(sec) (TRSP; MIM 165060) byseryl-tRNA synthetase (SARS; MIM 607529) to give ser-tRNA(sec),which is subsequently phosphorylated by O-phosphoseryl-tRNA kinase(PSTK; MIM 611310) to give O-phosphoseryl-tRNA(sec). SEPSECScatalyzes the final step of sec synthesis by convertingO-phosphoseryl-tRNA(sec) to selenocysteinyl-tRNA(sec) usingselenophosphate as the selenium donor (Palioura et al., 2009[PubMed 19608919]).
References
Agamy, O., et al. Am. J. Hum. Genet. 87(4):538-544(2010)Hart, K., et al. Lung Cancer (2010) In press :Volkmann, M., et al. J. Autoimmun. 34(1):59-65(2010)Palioura, S., et al. Science 325(5938):321-325(2009)Xu, X.M., et al. PLoS Biol. 5 (1), E4 (2007) :
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