|Other Names||O-phosphoseryl-tRNA(Sec) selenium transferase, Liver-pancreas antigen, LP, SLA-p35, SLA/LP autoantigen, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase, Sep-tRNA:Sec-tRNA synthase, SepSecS, Soluble liver antigen, SLA, UGA suppressor tRNA-associated protein, tRNA(Ser/Sec)-associated antigenic protein, SEPSECS, TRNP48|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis.|
|Tissue Location||Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells|
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Provided below are standard protocols that you may find useful for product applications.
The 21st amino acid, selenocysteine (sec), is distinctfrom other amino acids because it lacks its own tRNA synthetase andis the only amino acid synthesized on its cognate tRNA. Synthesisof sec begins with acylation of tRNA(sec) (TRSP; MIM 165060) byseryl-tRNA synthetase (SARS; MIM 607529) to give ser-tRNA(sec),which is subsequently phosphorylated by O-phosphoseryl-tRNA kinase(PSTK; MIM 611310) to give O-phosphoseryl-tRNA(sec). SEPSECScatalyzes the final step of sec synthesis by convertingO-phosphoseryl-tRNA(sec) to selenocysteinyl-tRNA(sec) usingselenophosphate as the selenium donor (Palioura et al., 2009[PubMed 19608919]).
Agamy, O., et al. Am. J. Hum. Genet. 87(4):538-544(2010)Hart, K., et al. Lung Cancer (2010) In press :Volkmann, M., et al. J. Autoimmun. 34(1):59-65(2010)Palioura, S., et al. Science 325(5938):321-325(2009)Xu, X.M., et al. PLoS Biol. 5 (1), E4 (2007) :
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