|Other Names||Pre-mRNA-splicing factor SLU7, hSlu7, SLU7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.|
|Cellular Location||Nucleus. Cytoplasm. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules|
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Provided below are standard protocols that you may find useful for product applications.
Pre-mRNA splicing occurs in two sequentialtransesterification steps. The protein encoded by this gene is asplicing factor that has been found to be essential during thesecond catalytic step in the pre-mRNA splicing process. Itassociates with the spliceosome and contains a zinc knuckle motifthat is found in other splicing factors and is involved inprotein-nucleic acid and protein-protein interactions. [provided byRefSeq].
Alberstein, M., et al. RNA 13(11):1988-1999(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Shomron, N., et al. J. Cell. Sci. 118 (PT 6), 1151-1159 (2005) :Shomron, N., et al. Mol. Biol. Cell 15(8):3782-3795(2004)Chua, K., et al. Mol. Cell. Biol. 21(5):1509-1514(2001)
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