|Other Names||Diphosphoinositol polyphosphate phosphohydrolase 3-alpha, DIPP-3-alpha, DIPP3-alpha, hDIPP3alpha, Diadenosine 5', 5'''-P1, P6-hexaphosphate hydrolase 3-alpha, Diadenosine hexaphosphate hydrolase (AMP-forming), Nucleoside diphosphate-linked moiety X motif 10, Nudix motif 10, hAps2, NUDT10, APS2, DIPP3A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.|
|Tissue Location||Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is widely expressed|
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Provided below are standard protocols that you may find useful for product applications.
NUDT10 belongs to a subgroup of phosphohydrolases thatpreferentially attack diphosphoinositol polyphosphates (Hidaka etal., 2002 [PubMed 12105228]).
Kim, S.T., et al. Prostate 70(16):1729-1738(2010)Gudmundsson, J., et al. Nat. Genet. 40(3):281-283(2008)Eeles, R.A., et al. Nat. Genet. 40(3):316-321(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Ross, M.T., et al. Nature 434(7031):325-337(2005)
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