|Other Names||Scm-like with four MBT domains protein 1, hSFMBT, Renal ubiquitous protein 1, SFMBT1, RU1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis.|
|Tissue Location||Expressed in all cell lines and normal tissues tested, including the thymus.|
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This gene shares high similarity with the Drosophila Scm(sex comb on midleg) gene. It encodes a protein which contains fourmalignant brain tumor repeat (mbt) domains and may be involved inantigen recognition. Several alternative splice variants thatencode the same protein have been characterized. [provided byRefSeq].
Wu, S., et al. FEBS Lett. 581(17):3289-3296(2007)
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