|Other Names||Type-1 angiotensin II receptor-associated protein, AT1 receptor-associated protein, AGTRAP, ATRAP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles|
|Tissue Location||Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.|
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This gene encodes a transmembrane protein localized to theplasma membrane and perinuclear vesicular structures. The geneproduct interacts with the angiotensin II type I receptor andnegatively regulates angiotensin II signaling. Alternative splicingof this gene generates multiple transcript variants encodingdifferent isoforms.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Godin, C.M., et al. Mol. Pharmacol. 77(3):388-395(2010)Rabbitts, J.A., et al. J. Physiol. (Lond.) 587 (PT 22), 5441-5449 (2009) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Newton-Cheh, C., et al. Nat. Genet. 41(6):666-676(2009)
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