|Other Names||Fc receptor-like protein 1, FcR-like protein 1, FcRL1, Fc receptor homolog 1, FcRH1, IFGP family protein 1, hIFGP1, Immune receptor translocation-associated protein 5, CD307a, FCRL1, FCRH1, IFGP1, IRTA5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||FCRH1, IFGP1, IRTA5|
|Function||May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta Specifically expressed by mature B lineage cells with higher expression in naive versus memory B-cells (at protein level)|
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This gene encodes a member of the immunoglobulin receptorsuperfamily and is one of several Fc receptor-like glycoproteinsclustered on the long arm of chromosome 1. The encoded proteincontains three extracellular C2-like immunoglobulin domains, atransmembrane domain and a cytoplasmic domain with twoimmunoreceptor-tyrosine activation motifs. This protein may play arole in the regulation of cancer cell growth. Alternative splicingresults in multiple transcript variants.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Davila, S., et al. Genes Immun. 11(3):232-238(2010)Kazemi, T., et al. Cancer Immunol. Immunother. 58(6):989-996(2009)Kazemi, T., et al. Int. J. Cancer 123(9):2113-2119(2008)Du, X., et al. Blood 111(1):338-343(2008)
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