GCNT2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8N0V5 |
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Clone Names | 110826147 |
Gene ID | 2651 |
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Other Names | N-acetyllactosaminide beta-1, 6-N-acetylglucosaminyl-transferase, isoform A, N-acetylglucosaminyltransferase, I-branching enzyme, IGNT, GCNT2, GCNT5, II, NACGT1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GCNT2 |
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Synonyms | GCNT5, II, NACGT1 |
Function | Branching enzyme that converts linear into branched poly-N- acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. |
Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
Tissue Location | [Isoform B]: Expressed in lens epithelium cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the enzyme responsible for formation ofthe blood group I antigen. The i and I antigens are distinguishedby linear and branched poly-N-acetyllactosaminoglycans,respectively. The encoded protein is the I-branching enzyme, abeta-1,6-N-acetylglucosaminyltransferase responsible for theconversion of fetal i antigen to adult I antigen in erythrocytesduring embryonic development. Mutations in this gene have beenassociated with adult i blood group phenotype. Alternativelyspliced transcript variants encoding different isoforms have beendescribed.
References
Twu, Y.C., et al. Blood 110(13):4526-4534(2007)Wang, L., et al. Biochem. Biophys. Res. Commun. 331(4):958-963(2005)Pras, E., et al. Invest. Ophthalmol. Vis. Sci. 45(6):1940-1945(2004)Inaba, N., et al. Blood 101(7):2870-2876(2003)Yu, L.C., et al. Blood 101(6):2081-2088(2003)
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