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GCNT2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8N0V5
Clone Names 110826147
Additional Information
Gene ID 2651
Other Names N-acetyllactosaminide beta-1, 6-N-acetylglucosaminyl-transferase, isoform A, N-acetylglucosaminyltransferase, I-branching enzyme, IGNT, GCNT2, GCNT5, II, NACGT1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GCNT2
Synonyms GCNT5, II, NACGT1
Function Branching enzyme that converts linear into branched poly-N- acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells.
Cellular Location Golgi apparatus membrane; Single- pass type II membrane protein
Tissue Location [Isoform B]: Expressed in lens epithelium cells.
Research Areas
Citations (0)
citation

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Background

This gene encodes the enzyme responsible for formation ofthe blood group I antigen. The i and I antigens are distinguishedby linear and branched poly-N-acetyllactosaminoglycans,respectively. The encoded protein is the I-branching enzyme, abeta-1,6-N-acetylglucosaminyltransferase responsible for theconversion of fetal i antigen to adult I antigen in erythrocytesduring embryonic development. Mutations in this gene have beenassociated with adult i blood group phenotype. Alternativelyspliced transcript variants encoding different isoforms have beendescribed.

References

Twu, Y.C., et al. Blood 110(13):4526-4534(2007)Wang, L., et al. Biochem. Biophys. Res. Commun. 331(4):958-963(2005)Pras, E., et al. Invest. Ophthalmol. Vis. Sci. 45(6):1940-1945(2004)Inaba, N., et al. Blood 101(7):2870-2876(2003)Yu, L.C., et al. Blood 101(6):2081-2088(2003)

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$ 277.78
Cat# BP18452c
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