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HIST1H2BA Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96A08 |
|---|---|
| Clone Names | 110826190 |
| Gene ID | 255626 |
|---|---|
| Other Names | Histone H2B type 1-A, Histone H2B, testis, TSH2B1, Testis-specific histone H2B, HIST1H2BA, TSH2B |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | H2BC1 (HGNC:18730) |
|---|---|
| Function | Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity). Core component of nucleosome (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By similarity). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (By similarity). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear (PubMed:21249133). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P70696}. Chromosome {ECO:0000250|UniProtKB:P70696} |
| Tissue Location | Mainly expressed in testis, and the corresponding protein is also present in mature sperm (at protein level). Also found in some fat cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Histones are basic nuclear proteins that are responsiblefor the nucleosome structure of the chromosomal fiber ineukaryotes. Nucleosomes consist of approximately 146 bp of DNAwrapped around a histone octamer composed of pairs of each of thefour core histones (H2A, H2B, H3, and H4). The chromatin fiber isfurther compacted through the interaction of a linker histone, H1,with the DNA between the nucleosomes to form higher order chromatinstructures. This gene is intronless and encodes atestis/sperm-specific member of the histone H2B family. Transcriptsfrom this gene contain a palindromic termination element. [providedby RefSeq].
References
Kim, S.C., et al. Mol. Cell 23(4):607-618(2006)Pavri, R., et al. Cell 125(4):703-717(2006)Zhu, B., et al. Mol. Cell 20(4):601-611(2005)Golebiowski, F., et al. Mol. Cell. Biochem. 279 (1-2), 133-139 (2005) :Li, A., et al. Biochemistry 44(7):2529-2535(2005)
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