CTEN Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8IZW8 |
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Clone Names | 90415140 |
Gene ID | 84951 |
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Other Names | Tensin-4, C-terminal tensin-like protein, TNS4, CTEN |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TNS4 |
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Synonyms | CTEN |
Function | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). |
Cellular Location | Cell junction, focal adhesion. Cytoplasm, cytoskeleton |
Tissue Location | Expressed at low levels in colon (at protein level) (PubMed:19214987, PubMed:19487278). Expressed in prostate and placenta (PubMed:12154022). |
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Provided below are standard protocols that you may find useful for product applications.
Background
TNS4 may be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Li, Y., et al. Prostate 70(1):48-60(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Liao, Y.C., et al. Cancer Res. 69(11):4563-4566(2009)Martuszewska, D., et al. PLoS ONE 4 (2), E4350 (2009) :
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