|Other Names||Hematopoietically-expressed homeobox protein HHEX, Homeobox protein HEX, Homeobox protein PRH, HHEX, HEX, PRH, PRHX|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||HEX, PRH, PRHX|
|Function||Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity).|
|Tissue Location||Liver and promyelocytic leukemia cell line HL- 60.|
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This gene encodes a member of the homeobox family oftranscription factors, many of which are involved in developmentalprocesses. Expression in specific hematopoietic lineages suggeststhat this protein may play a role in hematopoietic differentiation.
Heni, M., et al. Diabetes 59(12):3247-3252(2010)Pechlivanis, S., et al. Arterioscler. Thromb. Vasc. Biol. 30(9):1867-1872(2010)Reitz, C., et al. Neurobiol. Aging (2010) In press :Gaudet, M.M., et al. Cancer Epidemiol. Biomarkers Prev. 19(8):2106-2109(2010)Gupta, V., et al. Ann. Hum. Genet. 74(4):361-368(2010)
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