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HHEX Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q03014 |
|---|---|
| Clone Names | 90625087 |
| Gene ID | 3087 |
|---|---|
| Other Names | Hematopoietically-expressed homeobox protein HHEX, Homeobox protein HEX, Homeobox protein PRH, HHEX, HEX, PRH, PRHX |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HHEX |
|---|---|
| Synonyms | HEX, PRH, PRHX |
| Function | Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor (By similarity). Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982). Establishes anterior identity at two levels; acts early to enhance canonical WNT- signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:12554669). May play a role in hematopoietic differentiation (PubMed:8096636). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P43120}. Nucleus, nuclear body. Cytoplasm |
| Tissue Location | Liver and promyelocytic leukemia cell line HL-60. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the homeobox family oftranscription factors, many of which are involved in developmentalprocesses. Expression in specific hematopoietic lineages suggeststhat this protein may play a role in hematopoietic differentiation.
References
Heni, M., et al. Diabetes 59(12):3247-3252(2010)Pechlivanis, S., et al. Arterioscler. Thromb. Vasc. Biol. 30(9):1867-1872(2010)Reitz, C., et al. Neurobiol. Aging (2010) In press :Gaudet, M.M., et al. Cancer Epidemiol. Biomarkers Prev. 19(8):2106-2109(2010)Gupta, V., et al. Ann. Hum. Genet. 74(4):361-368(2010)
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