HOXA1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P49639 |
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Clone Names | 91013121 |
Gene ID | 3198 |
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Other Names | Homeobox protein Hox-A1, Homeobox protein Hox-1F, HOXA1, HOX1F |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | HOXA1 |
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Synonyms | HOX1F |
Function | Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (PubMed:16155570). Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A and PKNOX1 (By similarity). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:P09022}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
In vertebrates, the genes encoding the class oftranscription factors called homeobox genes are found in clustersnamed A, B, C, and D on four separate chromosomes. Expression ofthese proteins is spatially and temporally regulated duringembryonic development. This gene is part of the A cluster onchromosome 7 and encodes a DNA-binding transcription factor whichmay regulate gene expression, morphogenesis, and differentiation.The encoded protein may be involved in the placement of hindbrainsegments in the proper location along the anterior-posterior axisduring development. Two transcript variants encoding two differentisoforms have been found for this gene, with only one of theisoforms containing the homeodomain region.
References
Rankin, J.K., et al. J AAPOS 14(1):78-80(2010)Muscarella, L.A., et al. Mol Autism 1 (1), 9 (2010) :Canu, E., et al. J Neuroimaging 19(4):353-358(2009)Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Chakrabarti, B., et al. Autism Res 2(3):157-177(2009)
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