|Other Names||Interleukin-34, IL-34, IL34, C16orf77|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.|
|Tissue Location||Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.|
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Provided below are standard protocols that you may find useful for product applications.
Interleukin-34 is a cytokine that promotes thedifferentiation and viability of monocytes and macrophages throughthe colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Linet al., 2008 [PubMed 18467591]).
Wei, S., et al. J. Leukoc. Biol. 88(3):495-505(2010)Lin, H., et al. Science 320(5877):807-811(2008)Lim, J., et al. Cell 125(4):801-814(2006)
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