|Other Names||Potassium voltage-gated channel subfamily E member 4, MinK-related peptide 3, Minimum potassium ion channel-related peptide 3, Potassium channel subunit beta MiRP3, KCNE4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.|
|Cellular Location||Membrane; Single-pass membrane protein|
|Tissue Location||Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart.|
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Voltage-gated potassium (Kv) channels represent the mostcomplex class of voltage-gated ion channels from both functionaland structural standpoints. Their diverse functions includeregulating neurotransmitter release, heart rate, insulin secretion,neuronal excitability, epithelial electrolyte transport, smoothmuscle contraction, and cell volume. This gene encodes a member ofthe potassium channel, voltage-gated, isk-related subfamily. Thismember is a type I membrane protein, and a beta subunit thatassembles with a potassium channel alpha-subunit to modulate thegating kinetics and enhance stability of the multimeric complex.This gene is prominently expressed in the embryo and in adultuterus.
Levy, D.I., et al. J. Physiol. (Lond.) 588 (PT 14), 2657-2668 (2010) :Sole, L., et al. J. Cell. Sci. 122 (PT 20), 3738-3748 (2009) :Trevino, L.R., et al. Nat. Genet. 41(9):1001-1005(2009)Manderfield, L.J., et al. J. Physiol. (Lond.) 587 (PT 2), 303-314 (2009) :Levy, D.I., et al. Am. J. Physiol. Renal Physiol. 295 (2), F380-F387 (2008) :
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