|Other Names||Ran-binding protein 17, RANBP17|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function as a nuclear transport receptor.|
|Cellular Location||Cytoplasm. Nucleus. Nucleus, nuclear pore complex|
|Tissue Location||Highly expressed in testis, moderately in pancreas and weakly in other tissues studied|
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Provided below are standard protocols that you may find useful for product applications.
The transport of protein and large RNAs through thenuclear pore complexes (NPC) is an energy-dependent and regulatedprocess. The import of proteins with a nuclear localization signal(NLS) is accomplished by recognition of one or more clusters ofbasic amino acids by the importin-alpha/beta complex; see MIM600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays akey role in NLS-dependent protein import. RAN-binding protein-17 isa member of the importin-beta superfamily of nuclear transportreceptors.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Kutay, U., et al. J. Biol. Chem. 275(51):40163-40168(2000)Koch, P., et al. Biochem. Biophys. Res. Commun. 278(1):241-249(2000)
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