|Other Names||UV radiation resistance-associated gene protein, p63, UVRAG|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1850a was selected from the N-term region of human Autophagy UVRAG. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Late endosome. Lysosome. Early endosome. Note=Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial|
|Tissue Location||Highly expressed in brain, lung, kidney and liver.|
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UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
Liang,C., et al. Nat. Cell Biol. 8 (7), 688-699 (2006)Ionov,Y., et al. Oncogene 23 (3), 639-645 (2004)Goi,T., et al. Surg. Today 33 (9), 702-706 (2003)Iida,A., et al. Hum. Genet. 106 (3), 277-287 (2000)Perelman,B., et al. Genomics 41 (3), 397-405 (1997)Bekri,S., et al. Cytogenet. Cell Genet. 79 (1-2), 125-131 (1997)Teitz,T., et al. Gene 87 (2), 295-298 (1990)
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