|Other Names||Kynurenine--oxoglutarate transaminase 1, Cysteine-S-conjugate beta-lyase, Glutamine transaminase K, GTK, Glutamine--phenylpyruvate transaminase, Kynurenine aminotransferase I, KATI, Kynurenine--oxoglutarate transaminase I, CCBL1|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.|
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This gene encodes a cytosolic enzyme that is responsiblefor the metabolism of cysteine conjugates of certain halogenatedalkenes and alkanes. This metabolism can form reactive metabolitesleading to nephrotoxicity and neurotoxicity. Increased levels ofthis enzyme have been linked to schizophrenia. Multiple transcriptvariants that encode different isoforms have been identified forthis gene.
Han, Q., et al. J. Med. Chem. 52(9):2786-2793(2009)Cooper, A.J., et al. Arch. Biochem. Biophys. 474(1):72-81(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Kapoor, R., et al. Brain Res. 1106(1):205-210(2006)Cooper, A.J., et al. Amino Acids 30(1):1-15(2006)
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