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CCBL1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q16773 |
|---|---|
| Clone Names | 100528178 |
| Gene ID | 883 |
|---|---|
| Other Names | Kynurenine--oxoglutarate transaminase 1, Cysteine-S-conjugate beta-lyase, Glutamine transaminase K, GTK, Glutamine--phenylpyruvate transaminase, Kynurenine aminotransferase I, KATI, Kynurenine--oxoglutarate transaminase I, CCBL1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KYAT1 (HGNC:1564) |
|---|---|
| Synonyms | CCBL1 |
| Function | Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others (PubMed:19338303, PubMed:28097769). Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites (PubMed:7883047). Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (PubMed:7883047). |
| Cellular Location | Cytoplasm, cytosol. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a cytosolic enzyme that is responsiblefor the metabolism of cysteine conjugates of certain halogenatedalkenes and alkanes. This metabolism can form reactive metabolitesleading to nephrotoxicity and neurotoxicity. Increased levels ofthis enzyme have been linked to schizophrenia. Multiple transcriptvariants that encode different isoforms have been identified forthis gene.
References
Han, Q., et al. J. Med. Chem. 52(9):2786-2793(2009)Cooper, A.J., et al. Arch. Biochem. Biophys. 474(1):72-81(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Kapoor, R., et al. Brain Res. 1106(1):205-210(2006)Cooper, A.J., et al. Amino Acids 30(1):1-15(2006)
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