|Other Names||Protein zwilch homolog, hZwilch, ZWILCH|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131).|
|Cellular Location||Chromosome, centromere, kinetochore|
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Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores.
Brendle, A., et al. Eur. J. Cancer 45(3):435-442(2009)Kops, G.J., et al. J. Cell Biol. 169(1):49-60(2005)Williams, B.C., et al. Mol. Biol. Cell 14(4):1379-1391(2003)
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