|Other Names||Protein zwilch homolog, hZwilch, ZWILCH|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131).|
|Cellular Location||Chromosome, centromere, kinetochore|
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Provided below are standard protocols that you may find useful for product applications.
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores.
Brendle, A., et al. Eur. J. Cancer 45(3):435-442(2009)Kops, G.J., et al. J. Cell Biol. 169(1):49-60(2005)Williams, B.C., et al. Mol. Biol. Cell 14(4):1379-1391(2003)
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