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CHMP5 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9NZZ3
Clone Names 110819053
Peptide ID 110819053
Additional Information
Gene ID 51510
Other Names Charged multivesicular body protein 5, Chromatin-modifying protein 5, SNF7 domain-containing protein 2, Vacuolar protein sorting-associated protein 60, Vps60, hVps60, CHMP5, C9orf83, SNF7DC2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHMP5
Synonyms C9orf83, SNF7DC2
Function Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.
Cellular Location Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body
Research Areas
Citations (0)

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CHMP5 belongs to the chromatin-modifying protein/chargedmultivesicular body protein (CHMP) family. These proteins arecomponents of ESCRT-III (endosomal sorting complex required fortransport III), a complex involved in degradation of surfacereceptor proteins and formation of endocytic multivesicular bodies(MVBs). Some CHMPs have both nuclear and cytoplasmic/vesiculardistributions, and one such CHMP, CHMP1A (MIM 164010), is requiredfor both MVB formation and regulation of cell cycle progression(Tsang et al., 2006 [PubMed 16730941]).


Wang, H.R., et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 16(2):282-285(2008)Row, P.E., et al. J. Biol. Chem. 282(42):30929-30937(2007)Huang, H.H., et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 15(4):738-742(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Wang, H.R., et al. Oncology 71 (5-6), 423-429 (2006) :

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$ 80.00
Cat# BP18536b
(40 western blots)
Availability: In Stock
Bulk Size
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