|Other Names||Sodium/potassium/calcium exchanger 5, Na(+)/K(+)/Ca(2+)-exchange protein 5, Solute carrier family 24 member 5, SLC24A5, JSX, NCKX5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium- Calcium exchanger in melanocytes. Probably transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+).|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Melanosome. Note=Enriched in late-stage melanosomes|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the potassium-dependentsodium/calcium exchanger family and encodes an intracellularmembrane protein with 2 large hydrophilic loops and 2 sets ofmultiple transmembrane-spanning segments. Sequence variation inthis gene has been associated with differences in skinpigmentation.
Meda, S.A., et al. Neuroimage 53(3):1007-1015(2010)Nan, H., et al. Int. J. Cancer 125(4):909-917(2009)Dagle, J.M., et al. Pediatrics 123(4):1116-1123(2009)Gronskov, K., et al. Invest. Ophthalmol. Vis. Sci. 50(3):1058-1064(2009)Cook, A.L., et al. J. Invest. Dermatol. 129(2):392-405(2009)
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