|Other Names||Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4, Parvulin-14, Par14, hPar14, Parvulin-17, Par17, hPar17, Peptidyl-prolyl cis-trans isomerase Pin4, PPIase Pin4, Peptidyl-prolyl cis/trans isomerase EPVH, hEPVH, Rotamase Pin4, PIN4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA.|
|Cellular Location||Isoform 1: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Note=Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1|
|Tissue Location||Isoform 2 is much more stable than isoform 1 (at protein level). Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 transcripts are much more abundant than isoform 2 in each tissue analyzed.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the parvulin subfamily ofthe peptidyl-prolyl cis/trans isomerase protein family. The encodedprotein catalyzes the isomerization of peptidylprolyl bonds, andmay play a role in the cell cycle, chromatin remodeling, and/orribosome biogenesis. The encoded protein may play an additionalrole in the mitochondria.
Fujiyama-Nakamura, S., et al. Mol. Cell Proteomics 8(7):1552-1565(2009)Kessler, D., et al. BMC Biol. 5, 37 (2007) :Mueller, J.W., et al. BMC Mol. Biol. 7, 9 (2006) :Reimer, T., et al. J. Mol. Biol. 330(5):955-966(2003)Reimer, T., et al. J. Mol. Biol. 330(5):955-966(2003)
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