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RNF111 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6ZNA4
Clone Names 110819088
Peptide ID 110819088
Additional Information
Gene ID 54778
Other Names E3 ubiquitin-protein ligase Arkadia, 632-, RING finger protein 111, RNF111
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNF111 (HGNC:17384)
Function E3 ubiquitin-protein ligase (PubMed:26656854). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019, PubMed:16601693). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019, PubMed:16601693). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity). Activates SMAD3/SMAD4- dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (PubMed:17591695). Associates with UBE2D2 as an E2 enzyme (PubMed:22411132). Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23751493). Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (PubMed:23751493). Mediates ubiquitination and degradation of sumoylated PML (By similarity). The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity).
Cellular Location Nucleus. Cytoplasm. Nucleus, PML body {ECO:0000250|UniProtKB:Q99ML9}. Note=Upon TGF-beta treatment, translocates from nucleus to cytosol
Tissue Location Broadly expressed.
Research Areas
Citations (0)

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Background

The protein encoded by this gene contains a RING fingerdomain, a motif known to be involved in protein-protein andprotein-DNA interactions. The mouse counterpart of this gene(Rnf111/arkadia) has been shown to genetically interact with thetransforming growth factor (TGF) beta-like factor Nodal, and act asa modulator of the nodal signaling cascade, which is essential forthe induction of mesoderm during embryonic development. [providedby RefSeq].

References

Nagano, Y., et al. J. Biochem. 147(4):545-554(2010)Cunnington, R.H., et al. Can. J. Physiol. Pharmacol. 87(10):764-772(2009)Markson, G., et al. Genome Res. 19(10):1905-1911(2009)van Wijk, S.J., et al. Mol. Syst. Biol. 5, 295 (2009) :Liu, F.Y., et al. Kidney Int. 73(5):588-594(2008)

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$ 80.00
Cat# BP18547a
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