|Other Names||E3 ubiquitin-protein ligase NRDP1, 632-, RING finger protein 41, RNF41, FLRF, NRDP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor- independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).|
|Tissue Location||Detected in ovary, testis and prostate.|
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The protein encoded by this gene contains a RING finger, amotif present in a variety of functionally distinct proteins andknown to be involved in protein-protein and protein-DNAinteractions. The specific function of this protein has not yetbeen determined. Three alternatively spliced transcript variantsencoding two distinct isoforms have been reported. [provided byRefSeq].
Ingalla, E.Q., et al. J. Biol. Chem. 285(37):28691-28697(2010)Chen, L., et al. Cancer Res. 70(14):5994-6003(2010)Mo, X., et al. Parkinsonism Relat. Disord. 16(3):222-224(2010)Aharinejad, S., et al. Transplantation 89(2):245-252(2010)Yu, F., et al. Neurosci. Lett. 440(1):4-8(2008)
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