|Other Names||Interleukin-17 receptor C, IL-17 receptor C, IL-17RC, Interleukin-17 receptor homolog, IL17Rhom, Interleukin-17 receptor-like protein, IL-17RL, ZcytoR14, IL17RC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Activation of IL17RC leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1 (PubMed:16785495).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Soluble isoforms may be produced|
|Tissue Location||Expressed in prostate, skeletal muscle, kidney and placenta (at protein level) (PubMed:11706037). Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta, and prostate (PubMed:11706037). Also detected in thyroid, trachea and adrenal gland (PubMed:17911633). Low expression in thymus and leukocytes (PubMed:11706037)|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a single-pass transmembrane protein thatshares limited similarity with the interleukin-17 receptor.Multiple alternatively spliced transcript variants encodingdifferent isoforms have been detected for this gene, but thefull-length nature of only three have been determined to date.
Pickens, S.R., et al. J. Immunol. 184(6):3233-3241(2010)Wright, J.F., et al. J. Immunol. 181(4):2799-2805(2008)Zrioual, S., et al. J. Immunol. 180(1):655-663(2008)Kuestner, R.E., et al. J. Immunol. 179(8):5462-5473(2007)Haudenschild, D.R., et al. Prostate 66(12):1268-1274(2006)
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