|Other Names||Interleukin-22 receptor subunit alpha-2, IL-22 receptor subunit alpha-2, IL-22R-alpha-2, IL-22RA2, Cytokine receptor class-II member 10, Cytokine receptor family 2 member 10, CRF2-10, Cytokine receptor family type 2, soluble 1, CRF2-S1, Interleukin-22-binding protein, IL-22BP, IL22BP, ZcytoR16, IL22RA2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.|
|Tissue Location||Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a soluble class IIcytokine receptor. This protein has been shown to specifically bindto interleukin 22 (IL22), block the interaction of IL22 with itscell surface receptor, and thus inhibit IL22 activity. This proteinfunctions as an IL22 antagonist, and may be important in theregulation of inflammatory response. Three alternatively splicedtranscript variants encoding distinct isoforms have been described.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Kingo, K., et al. J. Dermatol. Sci. 57(1):71-73(2010)Trynka, G., et al. Gut 58(8):1078-1083(2009)Endam, L.M., et al. Otolaryngol Head Neck Surg 140(5):741-747(2009)de Moura, P.R., et al. FEBS Lett. 583(7):1072-1077(2009)
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