|Other Names||Metallophosphoesterase 1, 31--, Post-GPI attachment to proteins factor 5, MPPE1, PGAP5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Metallophosphoesterase required for transport of GPI- anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.|
|Cellular Location||Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi- pass membrane protein. Note=Also localizes to endoplasmic reticulum exit site|
|Tissue Location||Expressed in brain.|
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Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
Lohoff, F.W., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (3), 830-836 (2010) :Fujita, M., et al. Cell 139(2):352-365(2009)Yosifova, A., et al. J Affect Disord 117 (1-2), 87-97 (2009) :Fortna, A., et al. PLoS Biol. 2 (7), E207 (2004) :Vuoristo, J.T., et al. Cytogenet. Cell Genet. 95 (1-2), 60-63 (2001) :
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