|Other Names||Delta(3, 5)-Delta(2, 4)-dienoyl-CoA isomerase, mitochondrial, 533-, ECH1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4- trans-dienoyl-CoA.|
|Cellular Location||Mitochondrion. Peroxisome|
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This gene encodes a member of the hydratase/isomerasesuperfamily. The gene product shows high sequence similarity toenoyl-coenzyme A (CoA) hydratases of several species, particularlywithin a conserved domain characteristic of these proteins. Theencoded protein, which contains a C-terminal peroxisomal targetingsequence, localizes to the peroxisome. The rat ortholog, whichlocalizes to the matrix of both the peroxisome and mitochondria,can isomerize 3-trans,5-cis-dienoyl-CoA to2-trans,4-trans-dienoyl-CoA, indicating that it is adelta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions inthe auxiliary step of the fatty acid beta-oxidation pathway.Expression of the rat gene is induced by peroxisome proliferators.
Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Kovalyov, L.I., et al. Biochemistry Mosc. 71(4):448-453(2006)Goehler, H., et al. Mol. Cell 15(6):853-865(2004)Jia, Y., et al. J. Biol. Chem. 278(47):47232-47239(2003)
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