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SLC25A23 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BV35 |
|---|---|
| Clone Names | 110811213 |
| Gene ID | 79085 |
|---|---|
| Other Names | Calcium-binding mitochondrial carrier protein SCaMC-3, Mitochondrial ATP-Mg/Pi carrier protein 2, Mitochondrial Ca(2+)-dependent solute carrier protein 2, Small calcium-binding mitochondrial carrier protein 3, Solute carrier family 25 member 23, SLC25A23, APC2, MCSC2, SCAMC3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC25A23 (HGNC:19375) |
|---|---|
| Function | Electroneutral antiporter that mediates the transport of adenine nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenine nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenine nucleotide-dependent metabolic pathways (PubMed:15123600). Also acts as a regulator of mitochondrial calcium uptake and can probably transport trace amounts of other divalent metal cations in complex with ATP (PubMed:24430870, PubMed:28695448). In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides (PubMed:15123600). |
| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
| Tissue Location | Expressed at low levels in most tissues examined, with highest expression in brain, skeletal muscle and pancreas |
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Provided below are standard protocols that you may find useful for product applications.
Background
Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria.
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)Del Arco, A. Biochem. J. 389 (PT 3), 647-655 (2005) :Bassi, M.T., et al. Gene 345(2):173-182(2005)Fiermonte, G., et al. J. Biol. Chem. 279(29):30722-30730(2004)del Arco, A., et al. J. Biol. Chem. 279(23):24701-24713(2004)
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