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TBC1D2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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  • CITATIONS
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Product Information
Primary Accession Q9BYX2
Clone Names 110811237
Peptide ID 110811237
Additional Information
Gene ID 55357
Other Names TBC1 domain family member 2A, Armus, Prostate antigen recognized and identified by SEREX 1, PARIS-1, TBC1D2, PARIS1, PP8997, TBC1D2A
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TBC1D2
Synonyms PARIS1, PP8997, TBC1D2A
Function Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion.
Cellular Location Cytoplasm. Cytoplasmic vesicle. Cell junction
Tissue Location Expressed in a broad range of tissues, especially in kidney, liver, lung and placenta. Also expressed in keratinocytes and epithelia-containing organs. Isoform 2 is differentially expressed in prostate normal and cancer cells (at protein level).
Research Areas
Citations (0)

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Background

TBC1D2 acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivativation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion.

References

Letra, A., et al. Am. J. Med. Genet. A 152A (7), 1701-1710 (2010) :Ishibashi, K., et al. Genes Cells 14(1):41-52(2009)Olsen, J.V., et al. Cell 127(3):635-648(2006)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Zhou, Y., et al. Biochem. Biophys. Res. Commun. 290(2):830-838(2002)

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$ 80.00
Cat# BP18590c
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