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TBC1D2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BYX2 |
|---|---|
| Clone Names | 110811237 |
| Gene ID | 55357 |
|---|---|
| Other Names | TBC1 domain family member 2A, Armus, Prostate antigen recognized and identified by SEREX 1, PARIS-1, TBC1D2, PARIS1, PP8997, TBC1D2A |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TBC1D2 |
|---|---|
| Synonyms | PARIS1, PP8997, TBC1D2A |
| Function | Acts as a GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion. |
| Cellular Location | Cytoplasm. Cytoplasmic vesicle. Cell junction |
| Tissue Location | Expressed in a broad range of tissues, especially in kidney, liver, lung and placenta. Also expressed in keratinocytes and epithelia-containing organs. Isoform 2 is differentially expressed in prostate normal and cancer cells (at protein level) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TBC1D2 acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivativation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion.
References
Letra, A., et al. Am. J. Med. Genet. A 152A (7), 1701-1710 (2010) :Ishibashi, K., et al. Genes Cells 14(1):41-52(2009)Olsen, J.V., et al. Cell 127(3):635-648(2006)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Zhou, Y., et al. Biochem. Biophys. Res. Commun. 290(2):830-838(2002)
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