|Other Names||Ras GTPase-activating-like protein IQGAP2, IQGAP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.|
|Tissue Location||Isoform 2 expression is enhanced in testis.|
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This gene encodes a member of the IQGAP family. Theprotein contains three IQ domains, one calponin homology domain,one Ras-GAP domain and one WW domain. It interacts with componentsof the cytoskeleton, with cell adhesion molecules, and with severalsignaling molecules to regulate cell morphology and motility.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Van Laer, L., et al. Eur. J. Hum. Genet. 18(6):685-693(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Jin, S.H., et al. Int. J. Cancer 122(5):1040-1046(2008)
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