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Mouse Kcnj11 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q61743
Clone Names 110819130
Peptide ID 110819130
Additional Information
Gene ID 16514
Other Names ATP-sensitive inward rectifier potassium channel 11, Inward rectifier K(+) channel Kir62, Potassium channel, inwardly rectifying subfamily J member 11, Kcnj11
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Kcnj11
Function This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (By similarity).
Cellular Location Membrane; Multi-pass membrane protein.
Research Areas
Citations (0)

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Background

This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity).

References

Hugill, A., et al. Diabetologia 53(11):2352-2356(2010)Li, J., et al. J. Biol. Chem. 285(37):28723-28730(2010)Marhfour, I., et al. Cell Tissue Res. 340(2):335-346(2010)Kurata, H.T., et al. PLoS Biol. 8 (2), E1000315 (2010) :Alekseev, A.E., et al. Cell Metab. 11(1):58-69(2010)

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$ 80.00
Cat# BP18601a
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