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Mouse Slc10a2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P70172 |
|---|---|
| Clone Names | 110819137 |
| Gene ID | 20494 |
|---|---|
| Other Names | Ileal sodium/bile acid cotransporter, Apical sodium-dependent bile acid transporter, ASBT, Ileal Na(+)/bile acid cotransporter, Ileal sodium-dependent bile acid transporter, IBAT, ISBT, Na(+)-dependent ileal bile acid transporter, Sodium/taurocholate cotransporting polypeptide, ileal, Solute carrier family 10 member 2, Slc10a2, Ntcp2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Slc10a2 |
|---|---|
| Synonyms | Ntcp2 |
| Function | Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine (PubMed:10101301). Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate (PubMed:10101301). Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids. Works collaboratively with the Na(+)- taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (By similarity). |
| Cellular Location | Membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in ileum.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Slc10a2 plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity).
References
Halpern, M.D., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (3), G623-G631 (2010) :Festing, M.H., et al. Genesis 47(12):858-863(2009)Cheng, X., et al. Drug Metab. Dispos. 37(11):2178-2185(2009)Sarwar, Z., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 297 (3), G532-G538 (2009) :Saeki, T., et al. Biosci. Biotechnol. Biochem. 73(7):1535-1540(2009)
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