|Other Names||Protein max, Class D basic helix-loop-helix protein 4, bHLHd4, Myc-associated factor X, MAX, BHLHD4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity.|
|Cellular Location||Nucleus. Cell projection, dendrite|
|Tissue Location||High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle|
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The protein encoded by this gene is a member of the basichelix-loop-helix leucine zipper (bHLHZ) family of transcriptionfactors. It is able to form homodimers and heterodimers with otherfamily members, which include Mad, Mxi1 and Myc. Myc is anoncoprotein implicated in cell proliferation, differentiation andapoptosis. The homodimers and heterodimers compete for a common DNAtarget site (the E box) and rearrangement among these dimer formsprovides a complex system of transcriptional regulation. Multiplealternatively spliced transcript variants have been described forthis gene but the full-length nature for some of them is unknown.
Ting, Y., et al. Biochem. Biophys. Res. Commun. 394(3):606-611(2010)Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)Yang, H., et al. Hepatology 49(3):860-870(2009)Polasek, O., et al. Croat. Med. J. 50(1):7-16(2009)Gordan, J.D., et al. Cancer Cell 11(4):335-347(2007)
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