|Other Names||Bcl2-associated agonist of cell death, BAD, Bcl-2-binding component 6, Bcl-xL/Bcl-2-associated death promoter, Bcl2 antagonist of cell death, Bad, Bbc6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.|
|Cellular Location||Mitochondrion outer membrane. Cytoplasm. Note=Colocalizes with HIF3A isoform 2 in the cytoplasm (PubMed:21546903). Upon phosphorylation, locates to the cytoplasm.|
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The protein encoded by this gene is a member of the BCL-2family. BCL-2 family members are known to be regulators ofprogrammed cell death. This protein positively regulates cellapoptosis by forming heterodimers with BCL-xL and BCL-2, andreversing their death repressor activity. Proapoptotic activity ofthis protein is regulated through its phosphorylation. Proteinkinases AKT and MAP kinase, as well as protein phosphatasecalcineurin were found to be involved in the regulation of thisprotein. Alternative splicing of this gene results in twotranscript variants which encode the same isoform. [provided byRefSeq].
Santidrian, A.F., et al. Blood 116(16):3023-3032(2010)Frenzel, A., et al. Blood 115(5):995-1005(2010)Quoyer, J., et al. J. Biol. Chem. 285(3):1989-2002(2010)Polzien, L., et al. J. Biol. Chem. 284(41):28004-28020(2009)Wu, X., et al. Diabetologia 52(10):2130-2141(2009)
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