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SMN1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q16637
Clone Names 90625025
Peptide ID 90625025
Additional Information
Gene ID 6606;6607
Other Names Survival motor neuron protein, Component of gems 1, Gemin-1, SMN1, SMN, SMNT
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SMN1
Synonyms SMN, SMNT
Function The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
Cellular Location Cytoplasm. Nucleus, gem. Nucleus, Cajal body. Cytoplasmic granule. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with Actn at the Z-line of skeletal muscle (By similarity). Under stress conditions colocalizes with RPP20/POP7 in punctuated cytoplasmic granules Colocalized and redistributed with ZPR1 from the cytoplasm to nuclear gems (Gemini of coiled bodies) and Cajal bodies
Tissue Location Expressed in a wide variety of tissues. Expressed at high levels in brain, kidney and liver, moderate levels in skeletal and cardiac muscle, and low levels in fibroblasts and lymphocytes. Also seen at high levels in spinal cord. Present in osteoclasts and mononuclear cells (at protein level).
Research Areas
Citations (0)

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This gene is part of a 500 kb inverted duplication onchromosome 5q13. This duplicated region contains at least fourgenes and repetitive elements which make it prone to rearrangementsand deletions. The repetitiveness and complexity of the sequencehave also caused difficulty in determining the organization of thisgenomic region. The telomeric and centromeric copies of this geneare nearly identical and encode the same protein. However,mutations in this gene, the telomeric copy, are associated withspinal muscular atrophy; mutations in the centromeric copy do notlead to disease. The centromeric copy may be a modifier of diseasecaused by mutation in the telomeric copy. The critical sequencedifference between the two genes is a single nucleotide in exon 7,which is thought to be an exon splice enhancer. Note that the nineexons of both the telomeric and centromeric copies are designatedhistorically as exon 1, 2a, 2b, and 3-8. It is thought that geneconversion events may involve the two genes, leading to varyingcopy numbers of each gene. The protein encoded by this genelocalizes to both the cytoplasm and the nucleus. Within thenucleus, the protein localizes to subnuclear bodies called gemswhich are found near coiled bodies containing high concentrationsof small ribonucleoproteins (snRNPs). This protein formsheteromeric complexes with proteins such as SIP1 and GEMIN4, andalso interacts with several proteins known to be involved in thebiogenesis of snRNPs, such as hnRNP U protein and the smallnucleolar RNA binding protein. Two transcript variants encodingdistinct isoforms have been described.


Todd, A.G., et al. J. Mol. Biol. 401(5):681-689(2010)Sheng-Yuan, Z., et al. Eur. J. Hum. Genet. 18(9):978-984(2010)Liu, W.L., et al. Zhongguo Dang Dai Er Ke Za Zhi 12(7):539-543(2010)Wang, C.C., et al. Anal Bioanal Chem 397(6):2375-2383(2010)Bebee, T.W., et al. Front. Biosci. 15, 1191-1204 (2010) :

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$ 80.00
Cat# BP18621b
(40 western blots)
Availability: In Stock
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