|Other Names||Protein canopy homolog 3, CTG repeat protein 4a, Expanded repeat-domain protein CAG/CTG 5, Protein associated with TLR4, Trinucleotide repeat-containing gene 5 protein, CNPY3, CTG4A, ERDA5, PRAT4A, TNRC5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CTG4A, ERDA5, PRAT4A, TNRC5|
|Function||Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity).|
|Cellular Location||Endoplasmic reticulum.|
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Provided below are standard protocols that you may find useful for product applications.
PRAT4A is associated with the immature form of TLR4 (MIM603030) and regulates its cell surface expression (Wakabayashi etal., 2006 [PubMed 16849487]).
Wakabayashi, Y., et al. J. Immunol. 177(3):1772-1779(2006)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Zhang, H., et al. Nat. Biotechnol. 21(6):660-666(2003)Zhang, H., et al. Nat. Biotechnol. 21(6):660-666(2003)Margolis, R.L., et al. Hum. Genet. 100(1):114-122(1997)
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