|Other Names||Polypeptide N-acetylgalactosaminyltransferase 14, Polypeptide GalNAc transferase 14, GalNAc-T14, pp-GaNTase 14, Protein-UDP acetylgalactosaminyltransferase 14, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14, GALNT14|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Detected in renal tubules (at protein level). Highly expressed in fetal and adult kidney. Widely expressed at low level. Weakly expressed in whole brain, cerebellum, thymus, lung, mammary gland, liver, stomach, small intestine, colon, pancreas, spleen, bladder, uterus, placenta, testis, ovary, skeletal muscle, leukocyte, B-cell, bone marrow, fetal brain, fetal thymus, fetal lung, fetal liver, fetal small intestine, fetal spleen, fetal skeletal and fetus. Detected in renal tubules (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
GALNT14 (EC 220.127.116.11) belongs to a large subfamily ofglycosyltransferases residing in the Golgi apparatus. GALNT enzymescatalyze the first step in the O-glycosylation of mammalianproteins by transferring N-acetyl-D-galactosamine (GalNAc) topeptide substrates.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Stern, H.M., et al. Clin. Cancer Res. 16(5):1587-1596(2010)Wu, C., et al. BMC Cancer 10, 123 (2010) :Wu, C., et al. J. Biosci. 34(3):389-395(2009)Wu, C., et al. Biochem. Biophys. Res. Commun. 357(2):360-365(2007)
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