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KBTBD7 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8WVZ9
Clone Names 110717086
Additional Information
Gene ID 84078
Other Names Kelch repeat and BTB domain-containing protein 7, KBTBD7
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KBTBD7 (HGNC:25266)
Function As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation (PubMed:25684205). By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (PubMed:25684205). Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex (PubMed:25684205).
Cellular Location Cytoplasm. Nucleus
Research Areas
Citations (0)
citation

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Background

The function of this protein is unknown.

References

Hu, J., et al. BMB Rep 43(1):17-22(2010)Stelzl, U., et al. Cell 122(6):957-968(2005)

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$ 277.78
Cat# BP18640c
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