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SAP30L Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9HAJ7 |
|---|---|
| Clone Names | 110717172 |
| Gene ID | 79685 |
|---|---|
| Other Names | Histone deacetylase complex subunit SAP30L, HCV non-structural protein 4A-transactivated protein 2, Sin3 corepressor complex subunit SAP30L, Sin3-associated protein p30-like, SAP30L, NS4ATP2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SAP30L |
|---|---|
| Synonyms | NS4ATP2 |
| Function | [Isoform 1]: Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3- phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676). |
| Cellular Location | [Isoform 1]: Nucleus, nucleolus [Isoform 3]: Nucleus, nucleolus |
| Tissue Location | Detected in brain and ovary, and at lower levels in heart, small intestine, lung, kidney, skeletal muscle, stomach and spleen (at protein level) (PubMed:18070604). Ubiquitous; expressed in all tissues tested with highest levels in testis (PubMed:14680513) |
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Provided below are standard protocols that you may find useful for product applications.
Background
SAP30L is involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus.
References
Silva, L.K., et al. Eur. J. Hum. Genet. (2010) In press :Viiri, K.M., et al. Mol. Cell. Biol. 29(2):342-356(2009)Korkeamaki, H., et al. FEBS Lett. 582(2):379-384(2008)Assmann, E.M., et al. J. Biol. Chem. 281(15):9869-9881(2006)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
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