SEC23B Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q15437 |
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Clone Names | 110717177 |
Gene ID | 10483 |
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Other Names | Protein transport protein Sec23B, SEC23-related protein B, SEC23B |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SEC23B (HGNC:10702) |
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Function | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. |
Cellular Location | Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q15436}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15436}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15436}. Endoplasmic reticulum membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15436}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15436}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q15436} |
Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the SEC23subfamily of the SEC23/SEC24 family, which is involved in vesicletrafficking. The encoded protein has similarity to yeast Sec23pcomponent of COPII. COPII is the coat protein complex responsiblefor vesicle budding from the ER. The function of this gene producthas been implicated in cargo selection and concentration. Multiplealternatively spliced transcript variants have been identified inthis gene.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Fermo, E., et al. Blood Cells Mol. Dis. 45(1):20-22(2010)Bianchi, P., et al. Hum. Mutat. 30(9):1292-1298(2009)Schwarz, K., et al. Nat. Genet. 41(8):936-940(2009)Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
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