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AEBP2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6ZN18 |
|---|---|
| Clone Names | 110729023 |
| Gene ID | 121536 |
|---|---|
| Other Names | Zinc finger protein AEBP2, Adipocyte enhancer-binding protein 2, AE-binding protein 2, AEBP2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | AEBP2 |
|---|---|
| Function | Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:31959557, PubMed:29499137). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). |
| Cellular Location | Nucleus. Note=Localizes to chromatin as part of the PRC2 complex |
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Provided below are standard protocols that you may find useful for product applications.
Background
DNA-binding transcriptional repressor. AEBP2 may interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3.
References
Cao, R., et al. Mol. Cell 15(1):57-67(2004)He, G.P., et al. J. Biol. Chem. 274(21):14678-14684(1999)
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