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APOB48R Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q0VD83
Clone Names 110729027
Additional Information
Gene ID 55911
Other Names Apolipoprotein B receptor, Apolipoprotein B-100 receptor, Apolipoprotein B-48 receptor, Apolipoprotein B48 receptor, apoB-48R, APOBR, APOB48R
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name APOBR (HGNC:24087)
Synonyms APOB48R
Function Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages.
Cellular Location Cell membrane; Peripheral membrane protein. Note=Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein
Tissue Location Expressed in peripheral blood leukocytes > bone marrow = spleen > lymph node, and only faintly visible in appendix and thymus. Expressed in the brain, heart, kidney, liver, lung, pancreas, and placenta. Expressed primarily by reticuloendothelial cells: monocytes, macrophages, and endothelial cells. Expressed in atherosclerotic lesion foam cells.
Research Areas
Citations (0)
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Background

Apolipoprotein B48 receptor is a macrophage receptor thatbinds to the apolipoprotein B48 of dietary triglyceride (TG)-richlipoproteins. This receptor may provide essential lipids,lipid-soluble vitamins and other nutrients to reticuloendothelialcells. If overwhelmed with elevated plasma triglyceride, theapolipoprotein B48 receptor may contribute to foam cell formation,endothelial dysfunction, and atherothrombogenesis. [provided byRefSeq].

References

Kawakami, A., et al. Arterioscler. Thromb. Vasc. Biol. 25(2):424-429(2005)Fujita, Y., et al. J. Hum. Genet. 50(4):203-209(2005)Brown, M.L., et al. Proc. Natl. Acad. Sci. U.S.A. 97(13):7488-7493(2000)

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$ 277.78
Cat# BP18657c
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