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UHRF2 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96PU4
Clone Names 100517206
Peptide ID 100517206
Additional Information
Gene ID 115426
Other Names E3 ubiquitin-protein ligase UHRF2, 632-, Np95/ICBP90-like RING finger protein, Np95-like RING finger protein, Nuclear protein 97, Nuclear zinc finger protein Np97, RING finger protein 107, Ubiquitin-like PHD and RING finger domain-containing protein 2, Ubiquitin-like-containing PHD and RING finger domains protein 2, UHRF2, NIRF, RNF107
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UHRF2
Synonyms NIRF, RNF107
Function E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00358, ECO:0000269|PubMed:12176013, ECO:0000269|PubMed:23404503}. Note=Enriched at pericentric heterochromatin (PH). This localization is dependent on the interaction with H3K9me3 (By similarity).
Research Areas
Citations (0)

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This gene encodes a nuclear protein which is involved incell-cycle regulation. The encoded protein is a ubiquitin-ligasecapable of ubiquinating PCNP (PEST-containing nuclear protein), andtogether they may play a role in tumorigenesis. [provided byRefSeq].


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :He, X., et al. FEBS Lett. 583(21):3501-3507(2009)Iwata, A., et al. J. Biol. Chem. 284(15):9796-9803(2009)Unoki, M., et al. Oncogene 23(46):7601-7610(2004)Colland, F., et al. Genome Res. 14(7):1324-1332(2004)

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$ 80.00
Cat# BP18663c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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