|Other Names||Septin-6, SEPT6, KIAA0128, SEP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, spindle Chromosome, centromere, kinetochore Cleavage furrow. Midbody. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the septin family of GTPases.Members of this family are required for cytokinesis. One version ofpediatric acute myeloid leukemia is the result of a reciprocaltranslocation between chromosomes 11 and X, with the breakpointassociated with the genes encoding the mixed-lineage leukemia andseptin 2 proteins. This gene encodes four transcript variantsencoding three distinct isoforms. An additional transcript varianthas been identified, but its biological validity has not beendetermined.
Ding, X., et al. J. Biochem. Mol. Biol. 40(6):973-978(2007)Sirajuddin, M., et al. Nature 449(7160):311-315(2007)Kremer, B.E., et al. Cell 130(5):837-850(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Kim, C.S., et al. J. Virol. 81(8):3852-3865(2007)
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