Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
SEPT6 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q14141 |
|---|---|
| Clone Names | 110819095 |
| Gene ID | 23157 |
|---|---|
| Other Names | Septin-6, SEPT6, KIAA0128, SEP2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SEPTIN6 (HGNC:15848) |
|---|---|
| Synonyms | KIAA0128, SEP2, SEPT6 |
| Function | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton, spindle Chromosome, centromere, kinetochore Cleavage furrow. Midbody. Cell projection, cilium, flagellum. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. Found in the sperm annulus (PubMed:25588830). |
| Tissue Location | Widely expressed.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the septin family of GTPases.Members of this family are required for cytokinesis. One version ofpediatric acute myeloid leukemia is the result of a reciprocaltranslocation between chromosomes 11 and X, with the breakpointassociated with the genes encoding the mixed-lineage leukemia andseptin 2 proteins. This gene encodes four transcript variantsencoding three distinct isoforms. An additional transcript varianthas been identified, but its biological validity has not beendetermined.
References
Ding, X., et al. J. Biochem. Mol. Biol. 40(6):973-978(2007)Sirajuddin, M., et al. Nature 449(7160):311-315(2007)Kremer, B.E., et al. Cell 130(5):837-850(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Kim, C.S., et al. J. Virol. 81(8):3852-3865(2007)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
