|Other Names||Transcription factor IIIA, TFIIIA, GTF3A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNA's. May initiate transcription of the 5S ribosomal RNA gene and maintain the stability of transcription of other genes.|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene is a zinc finger protein withnine Cis-His zinc finger domains. It functions as an RNApolymerase III transcription factor to induce transcription of the5S rRNA genes. The protein binds to a 50 bp internal promoter inthe 5S genes called the internal control region (ICR), andnucleates formation of a stable preinitiation complex. This complexrecruits the TFIIIC and TFIIIB transcription factors and RNApolymerase III to form the complete transcription complex. Theprotein is thought to be translated using a non-AUG translationinitiation site in mammals based on sequence analysis, proteinhomology, and the size of the purified protein. [provided byRefSeq].
Wu, C., et al. Proteomics 7(11):1775-1785(2007)Newton-Cheh, C., et al. BMC Med. Genet. 8 SUPPL 1, S7 (2007) :Weser, S., et al. Nucleic Acids Res. 31(9):2408-2416(2003)Hanas, J.S., et al. Gene 282 (1-2), 43-52 (2002) :Moreland, R.J., et al. Nucleic Acids Res. 28(9):1986-1993(2000)
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