|Other Names||Trem-like transcript 1 protein, TLT-1, Triggering receptor expressed on myeloid cells-like protein 1, TREML1, TLT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface receptor that may play a role in the innate and adaptive immune response.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Cytoplasm. Note=Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151) Transported to the cell surface after stimulation by thrombin (PubMed:15100151). Soluble fragments can be released into the serum by proteolysis (PubMed:16505478)|
|Tissue Location||Detected in platelets, monocytic leukemia and in T-cell leukemia.|
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TREML1 is located in a gene cluster on chromosome 6 withthe single Ig variable (IgV) domain activating receptors TREM1 (MIM605085) and TREM2 (MIM 605086), but it has distinct structural andfunctional properties. TREML1 enhances calcium signaling in an SHP2(PTPN11; MIM 176876)-dependent manner (Allcock et al., 2003 [PubMed12645956]; Barrow et al., 2004 [PubMed 15128762]).[supplied byOMIM].
Morales, J., et al. Blood Coagul. Fibrinolysis 21(3):229-236(2010)Washington, A.V., et al. J. Clin. Invest. 119(6):1489-1501(2009)Ford, J.W., et al. Curr. Opin. Immunol. 21(1):38-46(2009)Nurden, A.T., et al. Thromb. Haemost. 100(1):45-51(2008)Giomarelli, B., et al. Thromb. Haemost. 97(6):955-963(2007)
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