|Other Names||Alpha-parvin, Actopaxin, Parva, Actp|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration. Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development.|
|Cellular Location||Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line Note=Constituent of focal adhesions|
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Provided below are standard protocols that you may find useful for product applications.
Parva probably plays a role in the regulation of cell adhesion and cytoskeleton organization.
Montanez, E., et al. EMBO J. 28(20):3132-3144(2009)Lange, A., et al. Nature 461(7266):1002-1006(2009)Stanchi, F., et al. J. Cell. Sci. 122 (PT 11), 1800-1811 (2009) :Pereira, J.A., et al. J. Cell Biol. 185(1):147-161(2009)Falco, G., et al. Reprod. Biomed. Online 13(3):394-403(2006)
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