|Other Names||Hyaluronan synthase 3, Hyaluronate synthase 3, Hyaluronic acid synthase 3, HA synthase 3, HAS3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is involved in thesynthesis of the unbranched glycosaminoglycan hyaluronan, orhyaluronic acid, which is a major constituent of the extracellularmatrix. This gene is a member of the NODC/HAS gene family. Comparedto the proteins encoded by other members of this gene family, thisprotein appears to be more of a regulator of hyaluronan synthesis.Alternative splicing results in multiple transcript variants.
Dunn, K.M., et al. Surgery 145(3):322-329(2009)Nykopp, T.K., et al. BMC Cancer 9, 143 (2009) :Nair, S., et al. J. Nephrol. 21(3):400-405(2008)Campo, G.M., et al. Mol. Cell. Biochem. 292 (1-2), 169-178 (2006) :Grskovic, B., et al. Biochim. Biophys. Acta 1760(6):890-895(2006)
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